On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias

Author:

Tian Xiaohe123ORCID,Leite Diana M.45ORCID,Scarpa Edoardo456ORCID,Nyberg Sophie457,Fullstone Gavin458,Forth Joe45ORCID,Matias Diana45ORCID,Apriceno Azzurra45ORCID,Poma Alessandro45ORCID,Duro-Castano Aroa45ORCID,Vuyyuru Manish59,Harker-Kirschneck Lena59ORCID,Šarić Anđela59ORCID,Zhang Zhongping310,Xiang Pan1,Fang Bin2,Tian Yupeng2,Luo Lei11,Rizzello Loris4512ORCID,Battaglia Giuseppe2451213ORCID

Affiliation:

1. School of Life Science, Anhui University, Hefei, P. R. China.

2. Department of Chemistry, Anhui University, Hefei, P. R. China.

3. Institute of Physical Science and Information Technology, Anhui University, Hefei, P. R. China.

4. Department of Chemistry, University College London, London, UK.

5. Institute for the Physics of Living Systems, University College London, London, UK.

6. SomaNautix Ltd., London, UK.

7. Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.

8. Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.

9. Department of Physics and Astronomy, University College London, London, UK.

10. CAS Center for Excellence in Nanoscience, Institute of Intelligent Machines, Chinese Academy of Science, Hefei, China.

11. College of Pharmaceutical Sciences, Southwest University, Chongqing, P. R. China.

12. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.

13. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

Abstract

Tubule formation acts as cargo transport across the blood-brain barrier.

Funder

H2020 European Research Council

H2020 Marie Skłodowska-Curie Actions

Engineering and Physical Sciences Research Council

CHILDREN with CANCER UK

Anhui 100 Talent

Royal Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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