Genetic history of Cambridgeshire before and after the Black Death-Reference-Cited by-同舟云学术

Genetic history of Cambridgeshire before and after the Black Death

Published:2024-01-19 Issue:3 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Hui Ruoyun¹²^ORCID,Scheib Christiana L.²³⁴^ORCID,D’Atanasio Eugenia⁵^ORCID,Inskip Sarah A.²⁶^ORCID,Cessford Craig²⁷^ORCID,Biagini Simone A.⁸^ORCID,Wohns Anthony W.⁹¹⁰^ORCID,Ali Muhammad Q.A.⁸,Griffith Samuel J.³^ORCID,Solnik Anu¹¹,Niinemäe Helja³,Ge Xiangyu Jack¹²,Rose Alice K.²¹³^ORCID,Beneker Owyn⁸^ORCID,O’Connell Tamsin C.²^ORCID,Robb John E.¹⁴,Kivisild Toomas²³⁸^ORCID

Affiliation:

1. Alan Turing Institute, London, UK.

2. McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.

3. Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.

4. St John’s College, University of Cambridge, Cambridge, UK.

5. Institute of Molecular Biology and Pathology, CNR, Rome, Italy.

6. School of Archaeology and Ancient History, University of Leicester, Leicester, UK.

7. Cambridge Archaeological Unit, Department of Archaeology, University of Cambridge, Cambridge, UK.

8. Department of Human Genetics, KU Leuven, Leuven, Belgium.

9. School of Medicine, Stanford University, Stanford, CA, USA.

10. Department of Genetics and Biology, Stanford University, Stanford, CA, USA.

11. Core Facility, Institute of Genomics, University of Tartu, Tartu, Estonia.

12. Wellcome Genome Campus, Wellcome Sanger Institute, Hinxton, UK.

13. Department of Archaeology, University of Durham, Durham, UK.

14. Department of Archaeology, University of Cambridge, Cambridge, UK.

Abstract

The extent of the devastation of the Black Death pandemic (1346–1353) on European populations is known from documentary sources and its bacterial source illuminated by studies of ancient pathogen DNA. What has remained less understood is the effect of the pandemic on human mobility and genetic diversity at the local scale. Here, we report 275 ancient genomes, including 109 with coverage >0.1×, from later medieval and postmedieval Cambridgeshire of individuals buried before and after the Black Death. Consistent with the function of the institutions, we found a lack of close relatives among the friars and the inmates of the hospital in contrast to their abundance in general urban and rural parish communities. While we detect long-term shifts in local genetic ancestry in Cambridgeshire, we find no evidence of major changes in genetic ancestry nor higher differentiation of immune loci between cohorts living before and after the Black Death.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adi5903

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