Structures and an activation mechanism of human potassium-chloride cotransporters-Reference-Cited by-同舟云学术

Structures and an activation mechanism of human potassium-chloride cotransporters

Published:2020-12-11 Issue:50 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Xie Yuan¹^ORCID,Chang Shenghai¹²^ORCID,Zhao Cheng¹,Wang Feng³,Liu Si⁴^ORCID,Wang Jin⁵,Delpire Eric⁶^ORCID,Ye Sheng⁴⁷^ORCID,Guo Jiangtao¹⁸^ORCID

Affiliation:

1. Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

2. Center of Cryo Electron Microscopy, Zhejiang University School of Medicine, Hangzhou 310058, China.

3. Wuxi Biortus Biosciences Co. Ltd., 6 Dongsheng West Road, Jiangyin, 214437, China.

4. Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China.

5. Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

6. Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

7. Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China.

8. Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.

Abstract

The full-length structures of human KCCs in an autoinhibition state suggest a potential activation mechanism.

Funder

National Institutes of Health

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Leducq Foundation

Laboratory and equipment management, Zhejiang University

Fundamental Research Funds for the Central Universities

Zhejiang Provincial Natural Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)