An ultrafast system for signaling mechanical pain in human skin

Author:

Nagi Saad S.123ORCID,Marshall Andrew G.45ORCID,Makdani Adarsh5ORCID,Jarocka Ewa6,Liljencrantz Jaquette78ORCID,Ridderström Mikael9ORCID,Shaikh Sumaiya13,O’Neill Francis10ORCID,Saade Dimah11ORCID,Donkervoort Sandra11,Foley A. Reghan11,Minde Jan9ORCID,Trulsson Mats12,Cole Jonathan13ORCID,Bönnemann Carsten G.11ORCID,Chesler Alexander T.7,Bushnell M. Catherine7ORCID,McGlone Francis514,Olausson Håkan12ORCID

Affiliation:

1. Center for Social and Affective Neuroscience, Linköping University, S-581 85 Linköping, Sweden.

2. Department of Clinical Neurophysiology, Linköping University Hospital, S-581 85 Linköping, Sweden.

3. School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia.

4. Faculty of Life Sciences, University of Manchester, M13 9PL Manchester, UK.

5. School of Natural Sciences and Psychology, Liverpool John Moores University, L3 3AF Liverpool, UK.

6. Department of Integrative Medical Biology, Umeå University, S-901 87 Umeå, Sweden.

7. National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892, USA.

8. Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, S-413 45 Gothenburg, Sweden.

9. Department of Surgery, Unit of Orthopedics, Perioperative Sciences, Umeå University Hospital, 901 85 Umeå, Sweden.

10. School of Dentistry, Institute of Clinical Sciences, University of Liverpool, L3 5PS Liverpool, UK.

11. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

12. Department of Dental Medicine, Karolinska Institute, S-141 04 Huddinge, Sweden.

13. Centre of Postgraduate Medical Research and Education, Bournemouth University, Poole BH12 5BB, UK.

14. Institute of Psychology, Health and Society, University of Liverpool, L3 5DA Liverpool, UK.

Abstract

Pain can be signaled as fast as touch in human peripheral nerves.

Funder

Pain Relief Foundation

Swedish Research Council Formas

NINDS

ALF Region Östergötland

Intramural Research Program of the NIH, specifically the NCCIH

DDIR Innovation Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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2. Experimental nerve block study on painful withdrawal reflex responses in humans;PLOS ONE;2024-08-16

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4. Slow touch and ultrafast pain fibres: Revisiting peripheral nerve classification;Clinical Neurophysiology;2024-07

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