Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation-Reference-Cited by-同舟云学术

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Published:2021-09-17 Issue:38 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Tapia-Abellán Ana¹²^ORCID,Angosto-Bazarra Diego¹^ORCID,Alarcón-Vila Cristina¹,Baños María C.¹^ORCID,Hafner-Bratkovič Iva³^ORCID,Oliva Baldomero⁴^ORCID,Pelegrín Pablo¹⁵^ORCID

Affiliation:

1. Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.

2. Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

3. Department of Synthetic Biology and Immunology, National Institute of Chemistry, EN-FIST Centre of Excellence, Ljubljana, Slovenia.

4. Laboratory of Structural Bioinformatics (GRIB), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain.

5. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia, 30120 Murcia, Spain.

Abstract

The specific NLRP3 N-terminal domain is essential for NLRP3 activation and inflammasome formation in response to K + efflux.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference50 articles.

1. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

2. Targeting the NLRP3 inflammasome in inflammatory diseases

3. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

4. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

5. Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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