An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse

Author:

Kallupi Marsida1ORCID,Xue Song2ORCID,Zhou Bin2ORCID,Janda Kim D.23,George Olivier1

Affiliation:

1. Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Departments of Chemistry and Immunology and Microbiology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

3. Worm Institute for Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

A bacterial enzyme that eats nicotine reverses addiction-like behaviors and offers a new strategy to help smokers quit.

Funder

National Institute on Drug Abuse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. What proportion of people who try one cigarette become daily smokers? A meta analysis of representative surveys;Birge M.;Nicotine Tob. Res.,2017

2. Postcessation cigarette use: The process of relapse;Brandon T. H.;Addict. Behav.,1990

3. Predictors of smoking relapse among self-quitters: A report from the Normative Aging Study;Garvey A. J.;Addict. Behav.,1992

4. Experimental model of smoking re-exposure: Effects on relapse;Chornock W. M.;Psychopharmacology (Berl),1992

5. The return to smoking: 1-Year relapse trajectories among female smokers;Conklin C. A.;Nicotine Tob. Res.,2005

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