Tb RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing-Reference-Cited by-同舟云学术

Tb RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing

Published:2020-09-18 Issue:38 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Afrin Marjia¹^ORCID,Gaurav Amit Kumar¹^ORCID,Yang Xian²,Pan Xuehua²^ORCID,Zhao Yanxiang²^ORCID,Li Bibo¹³⁴^ORCID

Affiliation:

1. Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.

2. Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People’s Republic of China.

3. Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

4. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract

The electrostatics-based dsDNA binding activity in Tb RAP1 NLS can be diminished by phosphorylation of NLS-adjacent S residues.

Funder

National Institutes of Health

Research Grants Council, University Grants Committee, Hong Kong

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

2. Identification of Human Rap1

3. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements

4. Fission yeast Rap1 homolog is a telomere-specific silencing factor and interacts with Taz1p;Park M. J.;Mol. Cells,2002

5. Rap1 in Candida albicans : an Unusual Structural Organization and a Critical Function in Suppressing Telomere Recombination

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