Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen-Reference-Cited by-同舟云学术

Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

Published:2021-02-19 Issue:8 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Augereau Adeline¹²^ORCID,Mariotti Marco¹^ORCID,Pousse Mélanie³,Filipponi Doria³,Libert Frédérick²,Beck Benjamin⁴,Gorbunova Vera⁵^ORCID,Gilson Eric³⁶^ORCID,Gladyshev Vadim N.¹^ORCID

Affiliation:

1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.

3. Université Côte d’Azur, CNRS, Inserm, Institute for Research on Cancer and Aging, Nice (IRCAN), 06107 Nice, France.

4. Welbio/FNRS at IRIBHM, 1070 Brussels, Belgium.

5. Department of Biology, University of Rochester, Rochester, NY 14627, USA.

6. Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, FHU Oncoage, 06107 Nice, France.

Abstract

Naked mole rat TRF1 enhances telomeric and metabolic functions in hypoxia through an evolutionary gain of function.

Funder

National Institute on Aging

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. How telomeres are replicated

2. Telomeres shorten during ageing of human fibroblasts

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4. Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

5. Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species

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