Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies-Reference-Cited by-同舟云学术

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Published:2021-04-16 Issue:16 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chen Guiqin¹²^ORCID,Kang Seong Su¹^ORCID,Wang Zhihao¹,Ahn Eun Hee¹^ORCID,Xia Yiyuan¹^ORCID,Liu Xia¹^ORCID,Sandoval Ivette M.³^ORCID,Manfredsson Fredric P.³^ORCID,Zhang Zhaohui²^ORCID,Ye Keqiang¹^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.

3. Parkinson’s Disease Research Unit, Department of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.

Abstract

Netrin-1 reduction activates AEP that cleaves UNC5C receptor, contributing to AD pathogenesis.

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Alzheimer’s Disease Research Center, Emory University

National Natural Science Foundation of China

National Institutes of Health under Award Number

National Institute of Health RF1

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

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4. Netrin-1: Diversity in development

5. Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

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