A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite-Reference-Cited by-同舟云学术

A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite

Published:2020-09-18 Issue:38 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kumar Sonu¹²³^ORCID,Ju Bin⁴⁵^ORCID,Shapero Benjamin¹^ORCID,Lin Xiaohe¹,Ren Li⁴,Zhang Lei¹,Li Dan⁴,Zhou Zehua⁵,Feng Yi⁴,Sou Cindy¹,Mann Colin J.¹^ORCID,Hao Yanling⁴,Sarkar Anita¹²³^ORCID,Hou Jiali⁴,Nunnally Christian¹,Hong Kunxue⁴,Wang Shuo⁴,Ge Xiangyang⁴,Su Bin⁶,Landais Elise²⁷⁸^ORCID,Sok Devin²³⁷⁸^ORCID,Zwick Michael B.⁷^ORCID,He Linling¹^ORCID,Zhu Jiang¹^ORCID,Wilson Ian A.¹²³⁹^ORCID,Shao Yiming⁴⁵¹⁰^ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.

4. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing 102206, China.

5. School of Medicine, Nankai University, Nankai District, Tianjin 300071, China.

6. Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui Province 230601, China.

7. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

8. International AIDS Vaccine Initiative, New York, NY 10004, USA.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

10. The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, China.

Abstract

BNAbs of V H 1-69 germline origin from a Chinese patient recognize the V3 glycan supersite via a disulfide-locked long HCDR3 loop.

Funder

National Institute of Allergy and Infectious Diseases

National Major Science and Technology Projects of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference93 articles.

1. Antibody responses to envelope glycoproteins in HIV-1 infection

2. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller