Clockophagy is a novel selective autophagy process favoring ferroptosis

Author:

Yang Minghua1ORCID,Chen Pan2,Liu Jiao3,Zhu Shan34,Kroemer Guido56789ORCID,Klionsky Daniel J.10ORCID,Lotze Michael T.2ORCID,Zeh Herbert J.11ORCID,Kang Rui11ORCID,Tang Daolin311ORCID

Affiliation:

1. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

2. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

3. The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510510, China.

4. Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

5. Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.

6. Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.

7. INSERM, U1138 Paris, France.

8. Université Pierre et Marie Curie, 75006 Paris, France.

9. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France.

10. Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

11. Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Autophagy-dependent cell death may hold the key to understanding the molecular basis of ferroptosis.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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