Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors-Reference-Cited by-同舟云学术

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Published:2016-01-07 Issue:1 Volume:127 Page:139-148
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Canli Özge¹,Alankuş Yasemin B.²,Grootjans Sasker³,Vegi Naidu⁴,Hültner Lothar⁵,Hoppe Philipp S.⁶,Schroeder Timm⁶,Vandenabeele Peter³,Bornkamm Georg W.⁵,Greten Florian R.¹

Affiliation:

1. Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany;

2. Institute of Clinical Chemistry, Klinikum rechts der Isar, Technical University Munich, Munich, Germany;

3. Department of Molecular Biomedical Research, VIB, VIB-Ghent University, Ghent (Zwijnaarde), Belgium;

4. Institute of Experimental Cancer Research, Comprehensive Cancer Center and University Hospital Ulm, Ulm, Germany;

5. Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, Munich, Germany; and

6. Department of Biosystems Science and Engineering, Swiss Federal Institute of Technology in Zurich, Basel, Switzerland

Abstract

Key Points Gpx4 is essential for preventing anemia in mice via inhibiting RIP3-dependent necroptosis in erythroid precursor cells. ROS accumulation and lipid peroxidation in erythroid precursor cells trigger receptor-independent activation of necroptosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/1/139/1391779/139.pdf

Reference50 articles.

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5. The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism.;Johnson;Free Radic Biol Med,2010

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