Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity-Reference-Cited by-同舟云学术

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Walker Caitlin¹^ORCID,Wang Yingjie¹²^ORCID,Olivieri Cristina¹^ORCID,Karamafrooz Adak¹^ORCID,Casby Jordan¹^ORCID,Bathon Kerstin³,Calebiro Davide⁴⁵^ORCID,Gao Jiali²⁶^ORCID,Bernlohr David A.¹,Taylor Susan S.⁷^ORCID,Veglia Gianluigi¹²^ORCID

Affiliation:

1. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

2. Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.

3. Institute for Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.

4. Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.

5. Centre of Membrane Proteins and Receptors, University of Birmingham, Birmingham B15 2TT, UK.

6. Shenzhen Bay Laboratory and Laboratory of Computational Chemistry and Drug Design, Peking University Graduate School, Shenzhen 518055, China.

7. Departments of Chemistry and Biochemistry and Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

A single mutation in protein kinase A remodels the intramolecular allostery, changing substrate specificity and regulation.

Funder

NIH Office of the Director

IKZF Wuerzburg

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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