Processed foods drive intestinal barrier permeability and microvascular diseases

Author:

Snelson Matthew1ORCID,Tan Sih Min1ORCID,Clarke Rachel E.2ORCID,de Pasquale Cassandra1,Thallas-Bonke Vicki1,Nguyen Tuong-Vi1,Penfold Sally A.1,Harcourt Brooke E.3ORCID,Sourris Karly C.1,Lindblom Runa S.1ORCID,Ziemann Mark4ORCID,Steer David5,El-Osta Assam1ORCID,Davies Michael J.6ORCID,Donnellan Leigh7,Deo Permal7ORCID,Kellow Nicole J.8ORCID,Cooper Mark E.1,Woodruff Trent M.9ORCID,Mackay Charles R.1011,Forbes Josephine M.12ORCID,Coughlan Melinda T.113ORCID

Affiliation:

1. Department of Diabetes, Central Clinical School, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Victoria, Australia.

2. Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

3. Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, Victoria, Australia.

4. Deakin University, School of Life and Environmental Sciences, Geelong, Victoria, Australia.

5. Monash Proteomics and Metabolomics Facility, Monash University, Melbourne, Victoria, Australia.

6. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

7. Health and Biomedical Innovation, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.

8. Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.

9. School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

10. Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

11. Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

12. Glycation and Diabetes Group, Mater Research Institute—The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.

13. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Abstract

This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.

Funder

Australian and New Zealand Society of Nephrology

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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