Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases-Reference-Cited by-同舟云学术

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Published:2020-02-21 Issue:8 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Klarić Lucija¹²^ORCID,Tsepilov Yakov A.³⁴^ORCID,Stanton Chloe M.²,Mangino Massimo⁵⁶^ORCID,Sikka Timo Tõnis⁷⁸^ORCID,Esko Tõnu⁷⁹¹⁰,Pakhomov Eugene³⁴^ORCID,Salo Perttu¹¹^ORCID,Deelen Joris¹²¹³^ORCID,McGurnaghan Stuart J.²,Keser Toma¹⁴^ORCID,Vučković Frano¹^ORCID,Ugrina Ivo¹¹⁵^ORCID,Krištić Jasminka¹,Gudelj Ivan¹,Štambuk Jerko¹,Plomp Rosina¹⁶,Pučić-Baković Maja¹^ORCID,Pavić Tamara¹⁴^ORCID,Vilaj Marija¹,Trbojević-Akmačić Irena¹^ORCID,Drake Camilla²,Dobrinić Paula¹⁷,Mlinarec Jelena¹⁷,Jelušić Barbara¹⁷^ORCID,Richmond Anne²,Timofeeva Maria¹⁸^ORCID,Grishchenko Alexander K.³⁴^ORCID,Dmitrieva Julia¹⁹,Bermingham Mairead L.²^ORCID,Sharapov Sodbo Zh.³^ORCID,Farrington Susan M.¹⁸,Theodoratou Evropi²⁰²¹^ORCID,Uh Hae-Won¹⁶²²^ORCID,Beekman Marian¹²^ORCID,Slagboom Eline P.¹²^ORCID,Louis Edouard²³,Georges Michel¹⁹^ORCID,Wuhrer Manfred¹⁶^ORCID,Colhoun Helen M.²²⁴,Dunlop Malcolm G.¹⁸^ORCID,Perola Markus¹¹^ORCID,Fischer Krista⁷^ORCID,Polasek Ozren²⁵²⁶²⁷,Campbell Harry²⁰,Rudan Igor²⁰,Wilson James F.²²⁰^ORCID,Zoldoš Vlatka¹⁷^ORCID,Vitart Veronique²^ORCID,Spector Tim⁵^ORCID,Aulchenko Yurii S.³²⁸²⁹^ORCID,Lauc Gordan¹¹⁴^ORCID,Hayward Caroline²³⁰^ORCID

Affiliation:

1. Genos Glycoscience Research Laboratory, Zagreb, Croatia.

2. MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

3. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.

4. Novosibirsk State University, 630090 Novosibirsk, Russia.

5. Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.

6. NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, UK.

7. Estonian Genome Center, University of Tartu, Tartu, Estonia.

8. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

9. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.

10. Division of Endocrinology, Boston Children’s Hospital, Cambridge, MA, USA.

11. Genomics and Biomarkers Unit, Department of Health, National Institute for Health and Welfare (THL), Helsinki, Finland.

12. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands.

13. Max Planck Institute for Biology of Ageing, Cologne, Germany.

14. Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.

15. University of Split, Faculty of Science, Split, Croatia.

16. Leiden University Medical Centre, Leiden, Netherlands.

17. Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.

18. Colon Cancer Genetics Group, Cancer Research UK Edinburgh Centre and Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

19. Unit of Animal Genomics, WELBIO, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

20. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

21. Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

22. Department of Biostatistics and Research Support, University Medical Center Utrecht, Utrecht, Netherlands.

23. CHU-Liège and Unit of Gastroenterology, GIGA-R and Faculty of Medicine, University of Liège, Liège, Belgium.

24. Department of Public Health, NHS Fife, Kirkcaldy, UK.

25. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.

26. Gen-info, Zagreb, Croatia.

27. Psychiatric Hospital Sveti Ivan, Zagreb, Croatia.

28. PolyOmica, Het Vlaggeschip 61, 5237 PA 's-Hertogenbosch, Netherlands.

29. Kurchatov Genomics Center, Institute of Cytology & Genetics, Novosibirsk, Russia.

30. Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Abstract

Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases.

Funder

American Friends of the Alexander von Humboldt Foundation

Horizon 2020 Framework Programme

Cancer Research UK

Chief Scientist Office

European Commission

Estonian Research Council

Ministry of Education and Science of the Russian Federation

Russian Science Foundation

European Regional Development Fund