Pseudogene-mediated DNA demethylation leads to oncogene activation-Reference-Cited by-同舟云学术

Pseudogene-mediated DNA demethylation leads to oncogene activation

Published:2021-10 Issue:40 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Kwon Junsu¹^ORCID,Liu Yanjing V.¹^ORCID,Gao Chong²^ORCID,Bassal Mahmoud A.¹³^ORCID,Jones Adrianna I.³^ORCID,Yang Junyu²,Chen Zhiyuan²,Li Ying¹,Yang Henry¹^ORCID,Chen Leilei¹^ORCID,Di Ruscio Annalisa⁴⁵⁶^ORCID,Tay Yvonne¹⁷^ORCID,Chai Li²^ORCID,Tenen Daniel G.¹³⁴^ORCID

Affiliation:

1. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

2. Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

3. Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.

4. Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.

5. Department of Translational Medicine, University of Eastern Piedmont, Novara 28100, Italy.

6. Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214, USA.

7. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.

Abstract

A pseudogene epigenetically regulates an oncogene by interacting with DNMT1 and affecting its methylation in a specific region.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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