Stochastic tunneling across fitness valleys can give rise to a logarithmic long-term fitness trajectory-Reference-Cited by-同舟云学术

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Stochastic tunneling across fitness valleys can give rise to a logarithmic long-term fitness trajectory

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Guo Yipei¹²^ORCID,Vucelja Marija³^ORCID,Amir Ariel¹^ORCID

Affiliation:

1. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. Program in Biophysics, Harvard University, Boston, MA 02115, USA.

3. Department of Physics, University of Virginia, Charlottesville, VA 22904, USA.

Abstract

Theoretical model suggests that gene interactions, known as epistasis, may dramatically slow down evolutionary dynamics.

Funder

National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.

1. The dynamics of adaptation on correlated fitness landscapes;Kryazhimskiy S.;Proc. Natl. Acad. Sci. U.S.A.,2009

2. Long-term dynamics of adaptation in asexual populations;Wiser M. J.;Science,2013

3. Generative models versus underlying symmetries to explain biological pattern;Frank S. A.;J. Evol. Biol.,2014

4. Number of adaptive steps to a local fitness peak;Jain K.;Europhys. Lett.,2011

5. Adaptive walks and extreme value theory;Neidhart J.;Phys. Rev. Lett.,2011

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