Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family-Reference-Cited by-同舟云学术

Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family

Published:2020-02-07 Issue:6 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yun Ji-Hye¹^ORCID,Ohki Mio²³^ORCID,Park Jae-Hyun¹^ORCID,Ishimoto Naito³^ORCID,Sato-Tomita Ayana⁴^ORCID,Lee Wonbin¹,Jin Zeyu¹^ORCID,Tame Jeremy R. H.³^ORCID,Shibayama Naoya⁴^ORCID,Park Sam-Yong³^ORCID,Lee Weontae¹^ORCID

Affiliation:

1. Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.

2. Research Complex at Harwell, Rutherford Appleton Laboratory, OX11 0FA Didcot, UK.

3. Drug Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Tsurumi, Yokohama 230-0045, Japan.

4. Division of Biophysics, Department of Physiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

Abstract

We identify the ion conduction pathway and protein dynamics in chloride pump NM-R3 using photoexcited crystals at 95 to 140 K.

Funder

Takeda Science Foundation

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

1. Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms

2. Rhodopsin-like Protein from the Purple Membrane of Halobacterium halobium

3. Halorhodopsin is a light-driven chloride pump.

4. Crystal Structure of the Light-Driven Chloride Pump Halorhodopsin from Natronomonas pharaonis

5. Crystal Structure of the Bromide-Bound D85S Mutant of Bacteriorhodopsin: Principles of Ion Pumping

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