Affiliation:
1. Secretory Physiology Section, Gene Therapy and Therapeutics Branch (GTTB), National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health, Bethesda, MD 20892, USA.
Abstract
Stimulation of cell surface receptors that increase phosphatidylinositol 4,5-bisphosphate (PIP
2
) hydrolysis leads to intracellular Ca
2+
release and activation of plasma membrane Ca
2+
entry channels. Ca
2+
entry via these channels regulates a wide array of physiological functions. The molecular composition of these channels and the mechanisms that activate or inactivate them have not yet been elucidated. Members of the TRPC subfamily of the TRP (transient receptor potential) family of proteins have been recently suggested as molecular components of these channels. In addition, Ca
2+
signaling proteins and the signals they generate are compartmentalized and spatiotemporally regulated. Thus, the mechanisms involved in the assembly and trafficking of Ca
2+
signaling proteins, including TRPC channels, will determine the regulation of Ca
2+
entry and its effect on cellular function.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献