Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy
Author:
Affiliation:
1. Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
2. University of Michigan Cancer Center, Ann Arbor, MI, USA.
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
General Medicine,Immunology
Link
https://www.science.org/doi/pdf/10.1126/sciimmunol.add8005
Reference55 articles.
1. Cancer immunotherapy using checkpoint blockade
2. FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis
3. In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy
4. Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments
5. FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model
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