In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

Published:2017-05-10 Issue:389 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Arlauckas Sean P.¹²³^ORCID,Garris Christopher S.¹⁴^ORCID,Kohler Rainer H.¹^ORCID,Kitaoka Maya⁵,Cuccarese Michael F.¹^ORCID,Yang Katherine S.¹^ORCID,Miller Miles A.¹²^ORCID,Carlson Jonathan C.¹,Freeman Gordon J.⁶^ORCID,Anthony Robert M.⁵,Weissleder Ralph¹²³^ORCID,Pittet Mikael J.¹²^ORCID

Affiliation:

1. Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

2. Department of Radiology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

3. Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

4. Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.

5. Center for Immunology and Infectious Disease, Massachusetts General Hospital, 149 8th Street, Charlestown, MA 02129, USA.

6. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Tumor-associated macrophages limit anti–PD-1 effects by removing the antibody from CD8 + T cells.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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