Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Author:

Knackstedt Sebastian Lorenz1ORCID,Georgiadou Athina2ORCID,Apel Falko1,Abu-Abed Ulrike3,Moxon Christopher A.45ORCID,Cunnington Aubrey J.2ORCID,Raupach Bärbel1,Cunningham Deirdre6,Langhorne Jean6,Krüger Renate7,Barrera Valentina8,Harding Simon P.8ORCID,Berg Aase9ORCID,Patel Sam10ORCID,Otterdal Kari11,Mordmüller Benjamin1213ORCID,Schwarzer Evelin14ORCID,Brinkmann Volker3ORCID,Zychlinsky Arturo1ORCID,Amulic Borko115ORCID

Affiliation:

1. Max Planck Institute for Infection Biology, Department of Cellular Microbiology, Charitéplatz 1, 10117 Berlin, Germany.

2. Section of Paediatrics, Imperial College London, London W21 PG, UK.

3. Max Planck Institute for Infection Biology, Microscopy Core Facility, Charitéplatz 1, 10117 Berlin, Germany.

4. Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

5. Institute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool L69 7BE, UK.

6. Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

7. Charité—Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Pneumology, Immunology and Intensive Care, Berlin, Germany.

8. Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

9. Stavanger University Hospital, Stavanger, Norway.

10. Maputo Central Hospital, Maputo, Mozambique.

11. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

12. Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.

13. Universität Tübingen, Institut für Tropenmedizin, Wilhelmstraße 27, 72074 Tübingen, Germany.

14. Department of Oncology, University of Turin, Via Santena 5 bis, 10126 Turin, Italy.

15. University of Bristol, School of Cellular and Molecular Medicine, Bristol BS8 1TD, UK.

Abstract

NETs contribute to malaria by promoting emergency granulopoiesis and endothelial binding of parasitized erythrocytes.

Funder

Medical Research Council

Max Planck Society

Western Norway Regional Health Authority

The National Center for Tropical Medicine and Imported Infectious Diseases, Bergen, Norway

The Medical Association for Infectious Diseases in Norway

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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