PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function

Author:

Bianchini Mariaelvy1ORCID,Duchêne Johan1ORCID,Santovito Donato1ORCID,Schloss Maximilian J.1,Evrard Maximilien23ORCID,Winkels Holger1ORCID,Aslani Maria1,Mohanta Sarajo K.1ORCID,Horckmans Michael1,Blanchet Xavier1ORCID,Lacy Michael1ORCID,von Hundelshausen Philipp14ORCID,Atzler Dorothee145,Habenicht Andreas1ORCID,Gerdes Norbert6ORCID,Pelisek Jaroslav7ORCID,Ng Lai Guan23,Steffens Sabine14,Weber Christian18ORCID,Megens Remco T. A.18ORCID

Affiliation:

1. Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität (LMU), 80336 Munich, Germany.

2. Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, 138648 Singapore.

3. School of Biological Sciences, Nanyang Technological University, 637551 Singapore.

4. German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80336 Munich, Germany.

5. Walther Straub Institute of Pharmacology and Toxicology, University of Munich, 80336 Munich, Germany.

6. Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.

7. Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

8. Cardiovascular Research Institute Maastricht, University of Maastricht, 6229 ER, Maastricht, Netherlands.

Abstract

PD-L1 + Ly6C lo monocytes derive from Ly6C hi monocytes in bone marrow and control T cell survival in tertiary lymphoid organs.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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