Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

Author:

Misawa Takuma1ORCID,SoRelle Jeffrey A.1,Choi Jin Huk1ORCID,Yue Tao1ORCID,Wang Kuan-wen1,McAlpine William1ORCID,Wang Jianhui1ORCID,Liu Aijie1ORCID,Tabeta Koichi2ORCID,Turer Emre E.1ORCID,Evers Bret3ORCID,Nair-Gill Evan1ORCID,Poddar Subhajit1ORCID,Su Lijing1ORCID,Ou Feiya1,Yu Liyang1ORCID,Russell Jamie1ORCID,Ludwig Sara1,Zhan Xiaoming1ORCID,Hildebrand Sara1ORCID,Li Xiaohong1ORCID,Tang Miao1ORCID,Murray Anne R.1ORCID,Moresco Eva Marie Y.1ORCID,Beutler Bruce1ORCID

Affiliation:

1. Center for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX 75390, USA.

2. Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.

3. Division of Neuropathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Prkd2-dependent phosphorylation of Bcl6 inhibits T FH cell differentiation.

Funder

National Institutes of Health

Uehara Memorial Foundation

Japan Society for the Promotion of Science

The Japanese Biochemical Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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