A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates-Reference-Cited by-同舟云学术

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates

Published:2021-07-29 Issue:61 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Pino Maria¹^ORCID,Abid Talha¹^ORCID,Pereira Ribeiro Susan²^ORCID,Edara Venkata Viswanadh¹³⁴^ORCID,Floyd Katharine¹³⁴^ORCID,Smith Justin C.⁵^ORCID,Latif Muhammad Bilal²,Pacheco-Sanchez Gabriela²,Dutta Debashis¹^ORCID,Wang Shelly¹^ORCID,Gumber Sanjeev²⁶,Kirejczyk Shannon²⁶^ORCID,Cohen Joyce⁷^ORCID,Stammen Rachelle L.⁷,Jean Sherrie M.⁷^ORCID,Wood Jennifer S.⁷^ORCID,Connor-Stroud Fawn⁷^ORCID,Pollet Jeroen⁸⁹^ORCID,Chen Wen-Hsiang⁸⁹^ORCID,Wei Junfei⁸⁹^ORCID,Zhan Bin⁸⁹^ORCID,Lee Jungsoon⁸⁹^ORCID,Liu Zhuyun⁸⁹^ORCID,Strych Ulrich⁸⁹^ORCID,Shenvi Neeta¹⁰,Easley Kirk¹⁰^ORCID,Weiskopf Daniela¹¹^ORCID,Sette Alessandro¹¹¹²^ORCID,Pollara Justin¹³^ORCID,Mielke Dieter¹³^ORCID,Gao Hongmei¹³^ORCID,Eisel Nathan¹³,LeBranche Celia C.¹³^ORCID,Shen Xiaoying¹³^ORCID,Ferrari Guido¹³,Tomaras Georgia D.¹³^ORCID,Montefiori David C.¹³^ORCID,Sekaly Rafick P.¹²,Vanderford Thomas H.¹,Tomai Mark A.¹⁴^ORCID,Fox Christopher B.¹⁵^ORCID,Suthar Mehul S.¹³⁴^ORCID,Kozlowski Pamela A.⁵,Hotez Peter J.⁸⁹,Paiardini Mirko¹²^ORCID,Bottazzi Maria Elena⁸⁹^ORCID,Kasturi Sudhir Pai¹²^ORCID

Affiliation:

1. Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, 954, Gatewood Rd, Atlanta, GA 30329, USA.

2. Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30329, USA.

3. Emory Vaccine Center at Emory University, 954, Gatewood Rd, Atlanta, GA 30329, USA.

4. Centers for Childhood Infections and Vaccines, Children’s Healthcare of Atlanta, and Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.

5. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

6. Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

7. Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

8. Texas Children’s Center for Vaccine Development, Houston, TX 77030, USA.

9. Department of Pediatrics, Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

10. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.

11. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

12. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.

13. Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27708, USA.

14. 3M Corporate Research Materials Laboratory, St. Paul, MN 55144-1000, USA.

15. Infectious Disease Research Institute, Seattle, WA 98109, USA.

Abstract

An adjuvanted monomeric RBD immunogen induces immunogenicity and protective immunity against SARS-CoV-2 in rhesus macaques.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Office of Public Affairs

Baylor University

Yerkes National Primate Research Center, Emory University

Childhood Infections and Vaccines Children Healthcare of Atlanta 712 Woodruff Health Sciences Center