A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses-Reference-Cited by-同舟云学术

A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

Published:2024-07-22 Issue:1 Volume:9 Page:
ISSN:2059-0105
Container-title:npj Vaccines
language:en
Short-container-title:npj Vaccines

Author:

Thimmiraju Syamala Rani,Adhikari Rakesh,Redd JeAnna R.,Villar Maria Jose,Lee Jungsoon,Liu Zhuyun,Chen Yi-Lin,Sharma Suman,Kaur Amandeep,Uzcategui Nestor L.,Ronca Shannon E.,Chen Wen-Hsiang^ORCID,Kimata Jason T.^ORCID,Zhan Bin,Strych Ulrich^ORCID,Bottazzi Maria Elena^ORCID,Hotez Peter J.,Pollet Jeroen

Abstract

AbstractThe development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41541-024-00924-x.pdf

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