Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium-Reference-Cited by-同舟云学术

Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium

Published:2024-07-12 Issue:97 Volume:9 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Liang Kaixin¹²³⁴⁵^ORCID,Barnett Katherine C.¹²³⁴^ORCID,Hsu Martin¹²³⁴^ORCID,Chou Wei-Chun¹²³⁴^ORCID,Bais Sachendra S.⁶^ORCID,Riebe Kristina⁷^ORCID,Xie Yuying⁸⁹^ORCID,Nguyen Tuong Thien¹⁰^ORCID,Oguin Thomas H.⁷^ORCID,Vannella Kevin M.¹¹¹²^ORCID,Hewitt Stephen M.¹³^ORCID,Chertow Daniel S.¹¹¹²^ORCID,Blasi Maria⁷¹⁴^ORCID,Sempowski Gregory D.⁷^ORCID,Karlsson Amelia⁷^ORCID,Koller Beverly H.¹²^ORCID,Lenschow Deborah J.⁶¹⁵¹⁶^ORCID,Randell Scott H.¹⁰^ORCID,Ting Jenny P.-Y.¹²³⁴^ORCID

Affiliation:

1. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Oral and Craniofacial Biomedicine Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63130, USA.

7. Duke Human Vaccine Institute, Durham, NC 27701, USA.

8. Department of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

9. Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA.

10. Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

11. Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

12. Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

13. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

14. Department of Medicine, Duke University School of Medicine, Durham, NC 27701, USA.

15. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

16. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Abstract

Virus-induced cell death is a key contributor to COVID-19 pathology. Cell death induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well studied in myeloid cells but less in its primary host cell type, angiotensin-converting enzyme 2 (ACE2)–expressing human airway epithelia (HAE). SARS-CoV-2 induces apoptosis, necroptosis, and pyroptosis in HAE organotypic cultures. Single-cell and limiting-dilution analysis revealed that necroptosis is the primary cell death event in infected cells, whereas uninfected bystanders undergo apoptosis, and pyroptosis occurs later during infection. Mechanistically, necroptosis is induced by viral Z-RNA binding to Z-DNA–binding protein 1 (ZBP1) in HAE and lung tissues from patients with COVID-19. The Delta (B.1.617.2) variant, which causes more severe disease than Omicron (B1.1.529) in humans, is associated with orders of magnitude–greater Z-RNA/ZBP1 interactions, necroptosis, and disease severity in animal models. Thus, Delta induces robust ZBP1-mediated necroptosis and more disease severity.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciimmunol.adn0178

Reference61 articles.

1. An inflammatory cytokine signature predicts COVID-19 severity and survival

2. COVID-19: Inflammatory Profile

3. Innate immunity and interferon in SARS-CoV-2 infection outcome

4. Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

5. Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves

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