A confusion of pathways: Discerning cell death mechanisms in SARS-CoV-2 infection-Reference-Cited by-同舟云学术

A confusion of pathways: Discerning cell death mechanisms in SARS-CoV-2 infection

Published:2024-07-12 Issue:97 Volume:9 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Wong Lok-Yin Roy¹²^ORCID,Perlman Stanley³⁴^ORCID

Affiliation:

1. Center for Virus-Host-Innate Immunity, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

2. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

3. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

4. Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

Abstract

Upon SARS-CoV-2 infection, infected cells undergo necroptosis, whereas delayed apoptosis and pyroptosis occur in uninfected, bystander cells, thus providing a plausible explanation for the extensive injury among myriad uninfected cells.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciimmunol.adp8170

Reference10 articles.

1. A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

2. Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium;Liang K.;Sci. Immunol.,2024

3. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

4. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses

5. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes