How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes-Reference-Cited by-同舟云学术

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes

Published:2019-04-12 Issue:34 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Wang Yang¹²^ORCID,Sosinowski Tomasz³,Novikov Andrey¹^ORCID,Crawford Frances¹,White Janice¹,Jin Niyun¹³^ORCID,Liu Zikou¹,Zou Jinhao¹^ORCID,Neau David⁴,Davidson Howard W.²³^ORCID,Nakayama Maki²³^ORCID,Kwok William W.⁵^ORCID,Gapin Laurent²,Marrack Philippa¹²⁶^ORCID,Kappler John W.¹²³⁷^ORCID,Dai Shaodong¹²⁷^ORCID

Affiliation:

1. Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.

2. Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

3. Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

4. Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.

5. Benaroya Research Institute, Seattle, WA 98101, USA.

6. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

7. Structural Biology and Biochemistry program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Abstract

In type 1 diabetes, mouse and human CD4 + T cells recognize mutated and chimeric superagonist insulin B-chain epitopes similarly.

Funder

Howard Hughes Medical Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

University of Colorado Denver

The Claire Friedlander Family Foundation

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Environmental Health Sciences

Boettcher Foundation

Colorado Clinical and Translational Sciences Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference57 articles.

1. Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes

2. The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form

3. Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

4. Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update

5. Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

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