SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques

Author:

Garrido Carolina1ORCID,Curtis Alan D.2ORCID,Dennis Maria1ORCID,Pathak Sachi H.2,Gao Hongmei1ORCID,Montefiori David1ORCID,Tomai Mark3ORCID,Fox Christopher B.4ORCID,Kozlowski Pamela A.5,Scobey Trevor6,Munt Jennifer E.6,Mallory Michael L.6ORCID,Saha Pooja T.7ORCID,Hudgens Michael G.7,Lindesmith Lisa C.6ORCID,Baric Ralph S.6ORCID,Abiona Olubukola M.8,Graham Barney S.8ORCID,Corbett Kizzmekia S.8ORCID,Edwards Darin9,Carfi Andrea9,Fouda Genevieve1ORCID,Van Rompay Koen K. A.10ORCID,De Paris Kristina2,Permar Sallie R.11

Affiliation:

1. Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA.

2. Department of Microbiology and Immunology, Center for AIDS Research, and Children’s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

3. 3M Corporate Research Materials Laboratory, Saint Paul, MN, USA.

4. Infectious Disease Research Institute, Seattle, WA, USA.

5. Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

6. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

7. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

8. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA.

9. Moderna Inc., Cambridge, MA, USA.

10. California National Primate Research Center, University of California, Davis, CA, USA.

11. Cornell Weill Medical College, New York, NY, USA.

Abstract

SARS-CoV-2 vaccines are well tolerated and highly immunogenic in infant rhesus macaques.

Funder

National Institutes of Health

National Cancer Institute

Office of Research Infrastructure Programs, National Institutes of Health

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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