TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes-Reference-Cited by-同舟云学术

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

Published:2020-05-19 Issue:47 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Zang Ruochen¹²^ORCID,Castro Maria Florencia Gomez¹,McCune Broc T.³^ORCID,Zeng Qiru¹,Rothlauf Paul W.¹⁴^ORCID,Sonnek Naomi M.⁵^ORCID,Liu Zhuoming¹^ORCID,Brulois Kevin F.⁶⁷^ORCID,Wang Xin²,Greenberg Harry B.⁷⁸^ORCID,Diamond Michael S.¹³⁹^ORCID,Ciorba Matthew A.⁵,Whelan Sean P. J.¹,Ding Siyuan¹^ORCID

Affiliation:

1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

2. Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, China.

3. Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

4. Program in Virology, Harvard Medical School, 200 Longwood Ave., Boston, MA, USA.

5. Division of Gastroenterology, Department of Medicine, Washington School of Medicine, St. Louis, MO, USA.

6. Department of Pathology, Stanford School of Medicine, Stanford, CA, USA.

7. VA Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, CA, USA.

8. Division of Gastroenterology and Hepatology, Department of Medicine, and Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA, USA.

9. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

The SARS-CoV-2 virus infects cultured ACE2-expressing human enterocytes aided by the TMPRSS2 and TMPRSS4 serine proteases.

Funder

National Institutes of Health

U.S. Department of Veterans Affairs

National Institute of Diabetes and Digestive and Kidney Diseases

Defense Advanced Research Projects Agency

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject