Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte–dendritic cell antigen presentation

Author:

Patel Dhiren F.1ORCID,Peiró Teresa12,Bruno Nicoletta1ORCID,Vuononvirta Juho1,Akthar Samia1,Puttur Franz1ORCID,Pyle Chloe J.1ORCID,Suveizdytė Kornelija1ORCID,Walker Simone A.1,Singanayagam Aran1ORCID,Carlin Leo M.34ORCID,Gregory Lisa G.1ORCID,Lloyd Clare M.1ORCID,Snelgrove Robert J.1ORCID

Affiliation:

1. Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.

2. Departamento de Enfermería, Universidad de Valencia, Valencia 46010, Spain.

3. Cancer Research UK Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.

4. Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK.

Abstract

G-CSF augments T H 2 responses in allergen-sensitized mice and is negatively regulated by transmigrated lung neutrophils.

Funder

European Commission Directorate-General for Research and Innovation

Wellcome

Medical Research Council

Cancer Research UK

British Lung Foundation

British Medical Association

Rosetrees Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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