The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis-Reference-Cited by-同舟云学术

The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis

Published:2021-07-29 Issue:61 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Bechara Rami¹^ORCID,Amatya Nilesh¹^ORCID,Bailey Rachel D.¹^ORCID,Li Yang¹^ORCID,Aggor Felix E. Y.¹^ORCID,Li De-Dong¹^ORCID,Jawale Chetan V.¹^ORCID,Coleman Bianca M.¹^ORCID,Dai Ning²,Gokhale Nandan S.³^ORCID,Taylor Tiffany C.¹^ORCID,Horner Stacy M.³⁴^ORCID,Poholek Amanda C.⁵^ORCID,Bansal Anita⁶^ORCID,Biswas Partha S.¹^ORCID,Gaffen Sarah L.¹^ORCID

Affiliation:

1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

2. Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.

3. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

4. Department of Medicine, Duke University Medical Center, Durham, NC, USA.

5. Division of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.

6. Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

The m6A “reader” IMP2 promotes cytokine-induced kidney autoimmunity by posttranscriptional control of C/EBPβ/δ transcription factors.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases