Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses

Author:

Slivka Peter F.1ORCID,Hsieh Chen-Lin2,Lipovsky Alex1,Pratt Steven D.3,Locklear John34,Namovic Marian T.3,McDonald Heath A.5,Wetter Joseph5,Edelmayer Rebecca5,Hu Min2,Murphy Erin2,Domanus Marc2,Lu Charles2,Duggan Ryan6,King Jacob1,Scott Victoria E.5,Donnelly-Roberts Diana3,Slavin Anthony7,Gopalakrishnan Sujatha3,Chung Namjin2,Goedken Eric R.1

Affiliation:

1. Discovery Dermatology & Fibrosis, AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States

2. Genomics Research Center, AbbVie Inc., North Chicago, Illinois 60064, United States

3. Target Enabling Science & Technology, AbbVie Inc., North Chicago, Illinois 60064, United States

4. PerkinElmer Life Sciences, Waltham, Massachusetts 02451, United States

5. Discovery Dermatology & Fibrosis, AbbVie Inc., North Chicago, Illinois 60064, United States

6. Immuno-Oncology Discovery, AbbVie Inc., North Chicago, Illinois 60064, United States

7. Immunology Pharmacology, AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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