Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells-Reference-Cited by-同舟云学术

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells

Published:2021-01-08 Issue:55 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Kusnadi Anthony¹^ORCID,Ramírez-Suástegui Ciro¹^ORCID,Fajardo Vicente¹^ORCID,Chee Serena J.²^ORCID,Meckiff Benjamin J.¹^ORCID,Simon Hayley¹,Pelosi Emanuela³,Seumois Grégory¹^ORCID,Ay Ferhat¹^ORCID,Vijayanand Pandurangan¹⁴⁵^ORCID,Ottensmeier Christian H.¹⁴^ORCID

Affiliation:

1. La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

2. NIHR and CRUK Southampton Experimental Cancer Medicine Center, Faculty of Medicine, University of Southampton, Southampton, UK.

3. Southampton Specialist Virology Centre, Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

4. Liverpool Head and Neck Center, Institute of Translational Medicine, University of Liverpool and Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, UK.

5. Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA.

Abstract

Fewer SARS-CoV-2–reactive memory CD8 + T cells with “exhaustion” features are present in patients with severe versus mild COVID-19.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Diseases

William K. Bowes Jr Foundation

Whittaker foundation

Publisher

American Association for the Advancement of Science (AAAS)