A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury

Author:

Ferrer Ivana R.1ORCID,West Heather C.1ORCID,Henderson Stephen2ORCID,Ushakov Dmitry S.3ORCID,Santos e Sousa Pedro1ORCID,Strid Jessica4ORCID,Chakraverty Ronjon1,Yates Andrew J.5,Bennett Clare L.1ORCID

Affiliation:

1. Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK and Cancer Institute Department of Haematology, Division of Cancer Studies, University College London, London WC1E 6DD, UK.

2. Bill Lyons Informatics Centre, Cancer Institute, University College London, London WC1E 6DD, UK.

3. Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, New Hunt's House, Newcomen Street, London SE1 1UL, UK.

4. Division of Immunology and Inflammation, Imperial College London, Hammersmith Campus, London W12 0NN, UK.

5. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

Abstract

Following immune damage in the epidermis, monocytes from the circulation give rise to epidermal Langerhans cells.

Funder

National Institutes of Health

Wellcome

Medical Research Council

Biotechnology and Biological Sciences Research Council

Bloodwise

Royal Free Charity

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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