SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses-Reference-Cited by-同舟云学术

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses

Published:2021-03-04 Issue:57 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Agerer Benedikt¹^ORCID,Koblischke Maximilian²^ORCID,Gudipati Venugopal³^ORCID,Montaño-Gutierrez Luis Fernando⁴^ORCID,Smyth Mark¹^ORCID,Popa Alexandra¹^ORCID,Genger Jakob-Wendelin¹^ORCID,Endler Lukas¹^ORCID,Florian David M.²,Mühlgrabner Vanessa³,Graninger Marianne²,Aberle Stephan W.²,Husa Anna-Maria⁴^ORCID,Shaw Lisa Ellen⁵^ORCID,Lercher Alexander¹^ORCID,Gattinger Pia⁶^ORCID,Torralba-Gombau Ricard¹^ORCID,Trapin Doris⁷,Penz Thomas¹,Barreca Daniele¹^ORCID,Fae Ingrid⁸^ORCID,Wenda Sabine⁸^ORCID,Traugott Marianna⁹^ORCID,Walder Gernot¹⁰,Pickl Winfried F.⁷¹¹,Thiel Volker¹²¹³,Allerberger Franz¹⁴^ORCID,Stockinger Hannes³^ORCID,Puchhammer-Stöckl Elisabeth²,Weninger Wolfgang⁵,Fischer Gottfried⁷^ORCID,Hoepler Wolfgang⁹^ORCID,Pawelka Erich⁸^ORCID,Zoufaly Alexander⁸,Valenta Rudolf³⁶¹¹¹⁵¹⁶,Bock Christoph¹¹⁷^ORCID,Paster Wolfgang⁴^ORCID,Geyeregger René⁴^ORCID,Farlik Matthias⁵^ORCID,Halbritter Florian⁴^ORCID,Huppa Johannes B.³^ORCID,Aberle Judith H.²,Bergthaler Andreas¹^ORCID

Affiliation:

1. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

2. Center for Virology, Medical University of Vienna, Vienna, Austria.

3. Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

4. St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria.

5. Department of Dermatology, Medical University of Vienna, Vienna, Austria.

6. Department of Pathophysiology and Allergy Research, Division of Immunopathology, Medical University of Vienna, Vienna, Austria.

7. Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

8. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.

9. Department of Medicine 4, Clinic Favoriten, Vienna, Austria.

10. Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.

11. Karl Landsteiner University of Health Sciences, Krems, Austria.

12. Institute of Virology and Immunology, Bern and Mittelhäusern, Switzerland.

13. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

14. Austrian Agency for Health and Food Safety (AGES), Vienna, Austria.

15. Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, First Moscow State Medical University Sechenov, Moscow, Russia.

16. NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

17. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

Abstract

SARS-CoV-2 mutations in MHC-I epitopes identified by deep viral sequencing evade CTL responses through decreased peptide-MHC-I binding.

Funder

H2020 European Research Council

European Research Council

Vienna Science and Technology Fund

Austrian Science Fund

Austrian Academy of Sciences

Scientific Fund of the Mayor of the federal capital Vienna

Medical-Scientific Fund of the Mayor of Vienna

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference68 articles.

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