Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications-Reference-Cited by-同舟云学术

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Published:2020-09-04 Issue:6508 Volume:369 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Mathew Divij¹²^ORCID,Giles Josephine R.¹²³^ORCID,Baxter Amy E.¹²^ORCID,Oldridge Derek A.¹⁴^ORCID,Greenplate Allison R.¹²^ORCID,Wu Jennifer E.¹²³^ORCID,Alanio Cécile¹²³^ORCID,Kuri-Cervantes Leticia¹⁵^ORCID,Pampena M. Betina¹⁵^ORCID,D’Andrea Kurt⁶^ORCID,Manne Sasikanth¹²,Chen Zeyu¹²,Huang Yinghui Jane¹²,Reilly John P.⁷,Weisman Ariel R.⁷^ORCID,Ittner Caroline A. G.⁷,Kuthuru Oliva¹²^ORCID,Dougherty Jeanette¹²^ORCID,Nzingha Kito¹²^ORCID,Han Nicholas¹²^ORCID,Kim Justin¹²^ORCID,Pattekar Ajinkya¹⁸^ORCID,Goodwin Eileen C.¹⁵,Anderson Elizabeth M.¹⁵^ORCID,Weirick Madison E.¹⁵^ORCID,Gouma Sigrid¹⁵,Arevalo Claudia P.¹⁵^ORCID,Bolton Marcus J.¹⁵^ORCID,Chen Fang⁹,Lacey Simon F.⁴⁹^ORCID,Ramage Holly¹⁰^ORCID,Cherry Sara¹⁴,Hensley Scott E.¹⁵^ORCID,Apostolidis Sokratis A.¹¹¹^ORCID,Huang Alexander C.¹³¹²,Vella Laura A.¹¹³^ORCID,Betts Michael R.¹⁵^ORCID,Meyer Nuala J.¹⁴^ORCID,Wherry E. John¹²³^ORCID,Alam Zahidul,Addison Mary M.,Byrne Katelyn T.,Chandra Aditi,Descamps Hélène C.,Kaminskiy Yaroslav,Hamilton Jacob T.,Noll Julia Han,Omran Dalia K.,Perkey Eric,Prager Elizabeth M.,Pueschl Dana,Shah Jennifer B.,Shilan Jake S.,Vanderbeck Ashley N.,

Affiliation:

1. Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

2. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

3. Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

4. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

5. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

6. Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

7. Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

8. Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

9. Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

10. Department of Microbiology, Thomas Jefferson University, Philadelphia, PA, USA.

11. Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

12. Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

13. Division of Infectious Disease, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA.

14. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

Funder

National Institutes of Health

Mark Foundation For Cancer Research

Cancer Research Institute

Allen Foundation

NHLBI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

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