Itaconate controls the severity of pulmonary fibrosis-Reference-Cited by-同舟云学术

Itaconate controls the severity of pulmonary fibrosis

Published:2020-10-08 Issue:52 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Ogger Patricia P.¹^ORCID,Albers Gesa J.¹²^ORCID,Hewitt Richard J.¹³^ORCID,O’Sullivan Brendan J.⁴⁵^ORCID,Powell Joseph E.⁶⁷,Calamita Emily¹^ORCID,Ghai Poonam¹,Walker Simone A.¹,McErlean Peter¹^ORCID,Saunders Peter³^ORCID,Kingston Shaun³^ORCID,Molyneaux Philip L.¹³^ORCID,Halket John M.⁸^ORCID,Gray Robert⁸^ORCID,Chambers Daniel C.⁴⁵,Maher Toby M.¹³⁹^ORCID,Lloyd Clare M.¹²^ORCID,Byrne Adam J.¹²^ORCID

Affiliation:

1. National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.

2. Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.

3. Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

4. Queensland Lung Transplant Service, Prince Charles Hospital, Brisbane, Queensland, Australia.

5. Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

6. Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia.

7. Cellular Genomics Futures Institute, University of New South Wales, Kensington, Sydney, Australia.

8. Mass Spectrometry Facility King’s College London, London SE1 9NH, UK.

9. Hastings Centre for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Abstract

The ACOD1/itaconate axis is a pulmonary regulatory pathway that controls the severity of fibrosis and is a potential therapeutic target in IPF.

Funder

Wellcome

National Health and Medical Research Council

Studienstiftung des Deutschen Volkes

NIHR Imperial Biomedical Research Centre

Joan Bending, Evelyn Bending, Mervyn Stephens + Olive Stephens Memorial Fellowship

Action for Pulmonary Fibrosis Mike Bray Fellowship

Wellcome Senior Fellow in Basic Biomedical Science

Publisher

American Association for the Advancement of Science (AAAS)