Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

Author:

Niyonzima Nathalie1ORCID,Rahman Jubayer2,Kunz Natalia2ORCID,West Erin E.2ORCID,Freiwald Tilo3ORCID,Desai Jigar V.4ORCID,Merle Nicolas S.2,Gidon Alexandre1,Sporsheim Bjørnar15ORCID,Lionakis Michail S.4ORCID,Evensen Kristin6ORCID,Lindberg Beate7ORCID,Skagen Karolina8,Skjelland Mona89ORCID,Singh Parul2,Haug Markus110ORCID,Ruseva Marieta M.11,Kolev Martin11,Bibby Jack2,Marshall Olivia12ORCID,O’Brien Brett12ORCID,Deeks Nigel12,Afzali Behdad3ORCID,Clark Richard J.13ORCID,Woodruff Trent M.13ORCID,Pryor Milton14,Yang Zhi-Hong14,Remaley Alan T.14ORCID,Mollnes Tom E.1151617ORCID,Hewitt Stephen M.18ORCID,Yan Bingyu19ORCID,Kazemian Majid19ORCID,Kiss Máté G.2021ORCID,Binder Christoph J.2021ORCID,Halvorsen Bente922ORCID,Espevik Terje110ORCID,Kemper Claudia223ORCID

Affiliation:

1. Center of Molecular Inflammation Research (CEMIR), Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

2. Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

3. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD 20892, USA.

4. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Central Administration, St. Olavs Hospital, University Hospital in Trondheim, Trondheim, Norway.

6. Department of Neurology, Vestre Viken, Drammen Hospital, Drammen, Norway.

7. Department of Cardiothoracic Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

8. Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

9. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

10. Central Norway Regional Health Authority, St. Olavs Hospital HF, Trondheim, Norway.

11. BG2, Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, UK.

12. Discovery DMPK Bioanalysis Unit, GlaxoSmithKline, Stevenage, UK.

13. School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

14. Lipoprotein Metabolism Section, Cardiopulmonary Branch, NHLBI, NIH, Bethesda, MD 20892, USA.

15. Department of Immunology, Oslo University Hospital, Rikshospitalet, and University of Oslo, Oslo, Norway.

16. Research Laboratory, Nordland Hospital, Bodø, Norway.

17. K.G. Jebsen TREC, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.

18. Laboratory of Pathology, National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.

19. Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN 47907, USA.

20. Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

21. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

22. Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

23. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.

Abstract

Mitochondrial C5aR1 signaling is required for proinflammatory macrophage activity during crystal-induced sterile inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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