Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
Author:
Funder
NIH Intramural Program
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-06706-z.pdf
Reference54 articles.
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2. Constant, S. L. & Bottomly, K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Ann. Rev. Immunol. 15, 297–322 (1997).
3. Murphy, K. M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674–680 (2010).
4. Cardone, J. et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 11, 862–871 (2010).
5. Kolev, M., Le Friec, G. & Kemper, C. The role of complement in CD4+ T cell homeostasis and effector functions. Semin. Immunol. 25, 12–19 (2013).
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