SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

Author:

Yan Bingyu1ORCID,Freiwald Tilo234ORCID,Chauss Daniel2,Wang Luopin5ORCID,West Erin3ORCID,Mirabelli Carmen6,Zhang Charles J.7ORCID,Nichols Eva-Maria8ORCID,Malik Nazish8ORCID,Gregory Richard8ORCID,Bantscheff Marcus8ORCID,Ghidelli-Disse Sonja8ORCID,Kolev Martin8ORCID,Frum Tristan9ORCID,Spence Jason R.910,Sexton Jonathan Z.79ORCID,Alysandratos Konstantinos D.1112,Kotton Darrell N.1112ORCID,Pittaluga Stefania13ORCID,Bibby Jack3,Niyonzima Nathalie14ORCID,Olson Matthew R.15,Kordasti Shahram1617ORCID,Portilla Didier218,Wobus Christiane E.6ORCID,Laurence Arian19ORCID,Lionakis Michail S.20ORCID,Kemper Claudia321ORCID,Afzali Behdad2ORCID,Kazemian Majid15ORCID

Affiliation:

1. Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.

2. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD 20892, USA.

3. Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

4. Department of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.

5. Department of Computer Science, Purdue University, West Lafayette, IN 20892, USA.

6. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 20892, USA.

7. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 20892, USA.

8. GlaxoSmithKline, Stevenage, UK.

9. Department of Internal Medicine, Michigan Medicine at University of Michigan, Ann Arbor, MI 20892, USA.

10. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 20892, USA.

11. Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.

12. Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

13. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.

14. Center of Molecular Inflammation Research (CEMIR), Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.

15. Department of Biological Sciences, Purdue University, West Lafayette, IN 20892, USA.

16. CRUK KHP Centre, Comprehensive Cancer Centre, King’s College London, London, UK.

17. Haematology Department, Guy’s Hospital, London, UK.

18. Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, VA 20892, USA.

19. Nuffield Department of Medicine, University of Oxford, Oxford, UK.

20. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA.

21. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.

Abstract

SARS-CoV-2 induces JAK-STAT1–dependent complement C3 transcription and processing by a cell-intrinsic alternative pathway convertase.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Malacological Society of London

Kaz Deutsche Forschungsgemeinschaft

NHLBI

NIGMS

NIDDK

NIAID

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3