‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

Author:

Mandal Swapna,Barnett Joseph,Brill Simon E,Brown Jeremy SORCID,Denneny Emma K,Hare Samanjit S,Heightman Melissa,Hillman Toby E,Jacob Joseph,Jarvis Hannah C,Lipman Marc C IORCID,Naidu Sindhu B,Nair Arjun,Porter Joanna CORCID,Tomlinson Gillian S,Hurst John RORCID

Abstract

Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.

Publisher

BMJ

Subject

Pulmonary and Respiratory Medicine

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