E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates

Author:

Wanet Anaïs1ORCID,Bassal Mahmoud A.12ORCID,Patel Sweta B.3ORCID,Marchi Francisco1ORCID,Mariani Samanta A.4,Ahmed Nouraiz5ORCID,Zhang Haoran1,Borchiellini Marta67ORCID,Chen Sisi1,Zhang Junyan1,Di Ruscio Annalisa789ORCID,Miyake Kensuke10ORCID,Tsai Mindy11,Paranjape Anuya11,Park Shin-Young12ORCID,Karasuyama Hajime10ORCID,Schroeder Timm5ORCID,Dzierzak Elaine4,Galli Stephen J.1113ORCID,Tenen Daniel G.12ORCID,Welner Robert S.3ORCID

Affiliation:

1. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

2. Cancer Science Institute of Singapore, National University of Singapore, Singapore.

3. Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, Birmingham, AL 35294, USA.

4. Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

5. Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

6. University of Eastern Piedmont, Department of Health Sciences, Novara 28100, Italy.

7. University of Eastern Piedmont, Department of Translational Medicine, Novara 28100, Italy.

8. Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.

9. Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

10. Inflammation, Infection, Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

11. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

12. Transfusion Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

13. Department of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

E-cadherin expression on mouse hematopoietic progenitors marks their commitment to the basophil and mast cell fates at an early stage.

Funder

NIH Office of the Director

BAEF

WBI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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