The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC-Reference-Cited by-同舟云学术

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Published:2020-02-04 Issue:617 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Meschede Jens¹^ORCID,Šadić Maria²^ORCID,Furthmann Nikolas¹^ORCID,Miedema Tim¹^ORCID,Sehr Dominik A.¹,Müller-Rischart A. Kathrin²,Bader Verian¹^ORCID,Berlemann Lena A.¹^ORCID,Pilsl Anna²,Schlierf Anita²,Barkovits Katalin³^ORCID,Kachholz Barbara¹,Rittinger Katrin⁴^ORCID,Ikeda Fumiyo⁵^ORCID,Marcus Katrin³,Schaefer Liliana⁶^ORCID,Tatzelt Jörg²⁷^ORCID,Winklhofer Konstanze F.¹²^ORCID

Affiliation:

1. Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, 44801 Bochum, Germany.

2. Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany.

3. Medizinisches Proteom-Center, Ruhr University Bochum, 44801 Bochum, Germany.

4. The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

5. Institute of Molecular Biotechnology (IMBA), 1030 Vienna, Austria.

6. Pharmacenter Frankfurt/ZAFES, Institute for General Pharmacology and Toxicology, Goethe University, 60590 Frankfurt am Main, Germany.

7. Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, 44801 Bochum, Germany.

Abstract

PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling.

Funder

Michael J. Fox Foundation for Parkinson’s Research

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference88 articles.

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