<scp>LUBAC</scp> assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of <scp>NF‐κB</scp> to the nucleus-Reference-Cited by-同舟云学术

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus

Published:2022-11-18 Issue:24 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Wu Zhixiao¹^ORCID,Berlemann Lena A¹,Bader Verian¹²^ORCID,Sehr Dominik A¹,Dawin Eva¹³,Covallero Alberto⁴,Meschede Jens¹,Angersbach Lena¹,Showkat Cathrin¹,Michaelis Jonas B⁵^ORCID,Münch Christian⁵^ORCID,Rieger Bettina⁶,Namgaladze Dmitry⁷,Herrera Maria Georgina¹,Fiesel Fabienne C⁸⁹,Springer Wolfdieter⁸⁹^ORCID,Mendes Marta¹⁰,Stepien Jennifer¹¹¹²,Barkovits Katalin¹¹¹²,Marcus Katrin¹¹¹²,Sickmann Albert³,Dittmar Gunnar¹⁰¹³^ORCID,Busch Karin B⁶,Riedel Dietmar¹⁴^ORCID,Brini Marisa¹⁵¹⁶^ORCID,Tatzelt Jörg²¹⁷^ORCID,Cali Tito⁴¹⁶¹⁸^ORCID,Winklhofer Konstanze F¹¹⁷^ORCID

Affiliation:

1. Department Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry Ruhr University Bochum Bochum Germany

2. Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry Ruhr University Bochum Bochum Germany

3. Leibniz‐Institut für Analytische Wissenschaften—ISAS—e.V Dortmund Germany

4. Department of Biomedical Sciences University of Padua Padua Italy

5. Faculty of Medicine, Institute of Biochemistry II Goethe University Frankfurt Frankfurt am Main Germany

6. Institute for Integrative Cell Biology and Physiology, Faculty of Biology University of Münster Münster Germany

7. Institute of Biochemistry I, Faculty of Medicine Goethe‐University Frankfurt Frankfurt Germany

8. Department of Neuroscience Mayo Clinic Jacksonville FL USA

9. Neuroscience PhD Program Mayo Clinic Graduate School of Biomedical Sciences Jacksonville FL USA

10. Proteomics of Cellular Signaling, Department of Infection and Immunity Luxembourg Institute of Health Strassen Luxembourg

11. Medizinisches Proteom‐Center Ruhr‐Universität Bochum Bochum Germany

12. Medical Proteome Analysis, Center for Protein Diagnostics (PRODI) Ruhr‐University Bochum Bochum Germany

13. Department of Life Sciences and Medicine University of Luxembourg Belvaux Luxembourg

14. Laboratory for Electron Microscopy Max Planck Institute for Multidisciplinary Sciences Göttingen Germany

15. Department of Biology University of Padua Padua Italy

16. Centro Studi per la Neurodegenerazione (CESNE) University of Padova Padua Italy

17. RESOLV Cluster of Excellence Ruhr University Bochum Bochum Germany

18. Padua Neuroscience Center (PNC) University of Padua Padua Italy

Funder

Congressionally Directed Medical Research Programs

Deutsche Forschungsgemeinschaft

National Institutes of Health

Michael J. Fox Foundation for Parkinson's Research

Ministero dell’Istruzione, dell’Università e della Ricerca

Università degli Studi di Padova

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2022112006

Reference120 articles.

1. Regulation of cGAS- and RLR-mediated immunity to nucleic acids

2. Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

3. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion

4. Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

5. Metabolism and Innate Immunity Meet at the Mitochondria

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