Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch-Reference-Cited by-同舟云学术

Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Published:2011-01-25 Issue:157 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hara Yoshikazu¹,Wakino Shu¹,Tanabe Yoshiyuki²,Saito Maki²,Tokuyama Hirobumi¹,Washida Naoki¹,Tatematsu Satoru¹,Yoshioka Kyoko¹,Homma Koichiro¹,Hasegawa Kazuhiro¹,Minakuchi Hitoshi¹,Fujimura Keiko¹,Hosoya Koji¹,Hayashi Koichi¹,Nakayama Koichi²,Itoh Hiroshi¹

Affiliation:

1. Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

2. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.

Abstract

Mechanical stretch activates Rho-kinase in adipocytes, promoting obesity and obesity-related complications.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. Obesity: the hormonal milieu

2. Adipocytokines and the Metabolic Complications of Obesity

3. Adipokines as emerging mediators of immune response and inflammation

4. Inflammation and metabolic disorders

5. Inflammation, stress, and diabetes

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