ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway-Reference-Cited by-同舟云学术

ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway

Published:2010-02-09 Issue:108 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kuo Hsu-Ping¹²,Lee Dung-Fang¹²,Chen Chun-Te¹²,Liu Mo¹²,Chou Chao-Kai¹²,Lee Hong-Jen¹²,Du Yi¹²,Xie Xiaoming¹³,Wei Yongkun¹,Xia Weiya¹,Weihua Zhang⁴,Yang Jer-Yen¹²,Yen Chia-Jui¹,Huang Tzu-Hsuan¹,Tan Minjia⁵,Xing Gang⁶,Zhao Yingming⁶,Lin Chien-Hsing⁷,Tsai Shih-Feng⁷,Fidler Isaiah J.²⁴,Hung Mien-Chie¹²⁸⁹

Affiliation:

1. Department of Molecular and Cellular Oncology, Unit 108, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

2. Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA.

3. Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510275, China.

4. Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

5. Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.

6. Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7. Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan.

8. Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung 404, Taiwan.

9. Asia University, Taichung 413, Taiwan.

Abstract

Acetylation by ARD1 of an inhibitor of mammalian target of rapamycin may inhibit cancer growth.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

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2. Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells

3. The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling

4. Control of p70 S6 kinase by kinase activity of FRAP in vivo

5. Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

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