Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis-Reference-Cited by-同舟云学术

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

Published:2014-09-02 Issue:341 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Svegliati Silvia¹,Marrone Giusi²,Pezone Antonio²,Spadoni Tatiana¹,Grieco Antonella¹,Moroncini Gianluca¹³,Grieco Domenico²,Vinciguerra Maria⁴,Agnese Savina²,Jüngel Astrid⁵,Distler Oliver⁵,Musti Anna Maria⁶,Gabrielli Armando¹³,Avvedimento Enrico V.²

Affiliation:

1. Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, 60126 Ancona, Italy.

2. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di napoli Federico II, 80132 Naples, Italy.

3. Dipartimento di Medicina Interna, Ospedali Riuniti, 60126 Ancona, Italy.

4. Cancer Research UK, Clare Hall, London EN6 3LD, UK.

5. Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, 8091 Zurich, Switzerland.

6. Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Arcavacata di Rende (CS) 87036, Italy.

Abstract

DNA damage not only promotes a mitotic checkpoint response but also activates a pathway that can produce fibrotic disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference58 articles.

1. Active Wnt proteins are secreted on exosomes

2. Wnt signaling controls the fate of mesenchymal stem cells

3. Secreted and Transmembrane Wnt Inhibitors and Activators

4. Secreted antagonists of the Wnt signalling pathway

5. A new secreted protein that binds to Wnt proteins and inhibits their activites

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