Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors-Reference-Cited by-同舟云学术

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

Published:2011-03-08 Issue:163 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sasaki Atsuo T.¹²,Carracedo Arkaitz³⁴,Locasale Jason W.¹²,Anastasiou Dimitrios¹²,Takeuchi Koh⁵⁶,Kahoud Emily Rose¹,Haviv Sasson¹,Asara John M.¹⁷,Pandolfi Pier Paolo³,Cantley Lewis C.¹²

Affiliation:

1. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Division of Genetics, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

4. CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio, Bizkaia, Spain.

5. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

6. Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, 2-3-26 Aomi, Koto, Tokyo 135-0064, Japan.

7. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Cancers in which K-Ras activation drives tumor growth could be targeted by treatments blocking K-Ras ubiquitination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference31 articles.

1. Ras oncogenes: split personalities

2. The Ras superfamily at a glance

3. The Guanine Nucleotide-Binding Switch in Three Dimensions

4. Recurrent KRAS codon 146 mutations in human colorectal cancer

5. Biochemical and Functional Characterization of Germ Line KRAS Mutations

Cited by 159 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Bioinformatic Analysis Predicts That Cannabidiol Could Function as a Potential Inhibitor of the MAPK Pathway in Colorectal Cancer;Current Issues in Molecular Biology;2024-08-05

2. Functional and structural insights into RAS effector proteins;Molecular Cell;2024-08

3. CALU promotes lung adenocarcinoma progression by enhancing cell proliferation, migration and invasion;Respiratory Research;2024-07-05

4. K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins;The EMBO Journal;2024-06-10

5. Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophila;Molecular Biology of the Cell;2024-03-01